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Patients were required to have at least 12 months continuous enrollment post-index date except for death (mean [standard deviation] follow-up period: 6.5 [2.7] years)

The high throughput screening campaign of the substance library provided several hit compounds one of those the drug-like aryl sulfonamide 40 that was subsequently optimized into 41 that is a metabolically stable and reversible IRAP inhibitor

Both processes depend on stable dopamine signaling and healthy function in the anterior cingulate cortex and dorsolateral prefrontal cortex

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